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1917, 1923, 1937 ORIGINAL COPIES OF THREE KEY EDITIONS OF JOSLIN'S GROUNDBREAKING TEXT ON TREATMENT OF DIABETES. Three hardcover volumes, each 9 1/2 inches tall, original cloth bindings: Second (1917), Third (1923) and Sixth (1937) editions. Unmarked except for previous owner's signature, and occasional underlinings in 1917 copy. Overall very good. Laid in 6th edition: Typescript (2 pages, folded), "Simplified Application of Insulin Treatment, American Congress on Internal Medicine, St. Louis, Clinic of Dr. O.P.J. Falk", with handwritten pencil notes on verso; 3x5 inches pink card table of nutritional content of foods, with instructions on verso; 3x5 inches card describing test and maintenance diets. CONTENTS OF EACH VOLUME: 1. DIETARY CONTROL: Second edition, enlarged and thoroughly revised (1917): The Treatment of Diabetes Mellitus, with observations on the disease based upon thirteen-hundred cases. Color frontis of test tubes showing lipid content in blood from diabetic patient. Printed on copyright page: 'It is desirable in peace, but a duty in war, every diabetic patient to keep sugar-free. The food which the untreated diabetic -patient wastes in a week would feed a soldier for a day. Dedication page: 'TO THE MEDICAL PROFESSION OF THE UNITED STATES OF AMERICA AND HER ALLIES UPON WHOM DEVOLVES THE TRAINING OF THEIR MILLION DIABETICS.' PREFACE TO THE SECOND EDITION. 'The more than kind reception accorded the first edition has led me to take even greater pains with the second. The book has therefore been largely rewritten, using as a basis tbe experience gained in another year of study of new and old diabetic cases. ... So-called acutely fatal diabetes is disappearing and the first year of diabetes is no longer, as was only too recently the case, the diabetic s danger zone. Already I have quite a series of patients who have outlived their normal expectation of life at the age of onset of their diabetes. ... In the United States there are, I suppose, not far from half a million individuals with diabetes or destined to have diabetes before they die. The care of them has devolved and will devolve almost wholly upon general practitioners.' 2. DISCOVERY OF INSULIN: Third edition, enlarged, revised and rewritten (1923): The Treatment of Diabetes Mellitus, with observations based upon three thousand casesDedication page: 'TO BANTING AND BEST and the TORONTO GROUP OF INSULIN WORKERS.' PREFACE TO THE THIRD EDITION. 'Today the men who have achieved progress in diabetes form a larger group than ever before in the history of the world. ... With such trained minds inter- ested in diabetes the time was ripe for new discoveries. Yet, can the reader imagine the feelings of a doctor with a background of 1000 fatal cases, who has lived to see what the ages have longed for come true in the discovery of insulin by F. G. Banting with the help of his student friend, C. H. Best. ... Insulin does not cure diabetes, but it is a priceless gift to the severe diabetic provided he be intelligent and faithful. Whereas formerly 10 per cent of all diabetics seen in a year died the same year, the mortality has now fallen to 6.7 per cent of my 293 patients treated with insulin. ... Yet insulin is in its infancy. New possibilities still continue to unfold. One accomplishes in hours what formerly took days. ... The unit: of insulin is changing as this book goes to press. It is hoped that the new unit will shortly be accepted as the international unit. ... A new and purer diabetes is described in this book. It is a diabetes largely free from many of the complications which crowd and confuse the older monographs. ... The privilege of recording results with insulin is obviously the chief delight in writing this new edition. For this I am indebted to the courtesy of the Insulin Committee of Toronto and through their intervention to the Eli Lilly Company.' 3. DISCOVERY OF PROTAMINE INSULIN: Sixth edition, thoroughly revised (1937):The Treatment of Diabetes Mellitus by Elliott P. Joslin, with the cooperation of Howard F. Root, Priscilla White, and Alexander Marble. PREFACE TO THE SIXTH EDITION. 'Protamine insulin necessitated the revision of this book. its value my associates and I are convinced, because we see in protamine insulin and other insulin compounds, which will follow in its train, the beginning for the diabetic of a new and better epoch-the Hagedorn Era. Protamine insulin today is the insulin for the general practitioner to use with the majority of his diabetics, although regular insulin must always be available to supplement it in coma, infections and emergencies, whether surgical, obstetrical or otherwise. ... Protamine insulin is not perfect, does not have brains, and given once in twenty-four hours may not replace the regular insulin which the meticulous patient, after years of experience, has learned to administer three or four times daily and in varying dosage to keep his diabetes controlled.' ELLIOTT PROCTER JOSLIN, M.D. (1869 - 1962) was the first doctor in the United States to specialize in diabetes and was the founder of today's Joslin Diabetes Center. Dr. Joslin was involved for seven decades in most every aspect of diabetes investigation and treatment, save for the fact that he did not discover insulin. Following the Toronto group's blockbuster discovery of insulin in 1921, and the group's disbanding several years later, Joslin became effectively the Dean of diabetes mellitus. In the mid 1920s, Joslin, in his mid 50s, took the reins as the world spokesman for the 'cause of diabetes.' He was the first to advocate for teaching patients to care for their own diabetes, an approach now commonly referred to as 'DSME' or Diabetes Self-Management Education. He is also a recognized pioneer in glucose management, identifying that tight glucose control leads to fewer and less extreme complications. From the beginning of his medical practice he kept a diabetes registry, the first of its kind in the world. His carefully assembled data from his medical ledgers eventually allowed him to predict a global diabetes epidemic that is evident today. In 1908, in conjunction with physiologist Francis G. Benedict, Joslin carried out extensive metabolic balance studies examining fasting and feeding in patients with varying severities of diabetes. Joslin included the findings from 1,000 of his own cases in his 1916 monograph The Treatment of Diabetes Mellitus, the first textbook on diabetes in the English language. Here he noted a 20 percent decrease in the mortality of patients after instituting a program of diet and exercise. This physician's handbook had 10 more editions in his lifetime and established Joslin as a world leader in diabetes. When insulin became available as therapy in 1922, Joslin's corps of nurses became the forerunners of certified diabetes educators, providing instruction in diet, exercise, foot care and insulin dosing, and established camps for children with diabetes throughout New England. With insulin available, Joslin enlarged his medical practice into a team that evolved into the Joslin Clinic that was affiliated with the New England Deaconess Hospital and the Harvard Medical School. Joslin was adamant in his position that good glucose control, achieved through a restricted carbohydrate diet, exercise, and frequent testing and insulin adjustment, would prevent complications. This was debated for decades by other endocrinologists and scientists, and the American Diabetes Association was divided on this subject from its inception. Joslin's approach wasn't validated until 30 years after his death, when in 1993, a 10-year study, the Diabetes Control and Complications Trial Report was published in the New England Journal of Medicine.