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1881 RARE AMERICAN TREATISE ON TREATMENT OF RABIES BEFORE PASTEUR'S VACCINATION OF A CHILD IN 1885. 8 inches tall hardcover, viii, 154 pages, original red pebbled cloth covers with blindstamped design and beveled edges. Spine darkened, spine ends worn, institutional bookplate on front paste-down, no other library marks, overall very good. A 19th century American treatise on the history and treatment of rabies published 4 years before Pasteur's successful vaccination of a child bitten by a rabid dog in 1885. Bigelow was unaware of Pasteur's early studies of rabies (beginning in 1880), and believed that the disease was primarily the result of a blood disorder, and not primarily the nervous tissue. The concluding paragraph: 'Recent pathology seems to sustain the opinion which I advanced in preceding chapters of this work. I have no reason to depart from such impression, and I still believe that if we are to treat hydrophobia successfully must do so by making use of those remedies which will act directly upon the blood. The primary excitant is a blood irritant, which addresses itself chiefly to the finer vessels supplying the central nervous system. Tlie condition of 'disorganization,' founded upon post-mortem examination of the cord, is an effect of the altered blood supply, and cannot now be regarded in any sense as a primary lesion.' 15 copies in WorldCat; no copies on Internet. The chapter titles summarize the state-of-the-art for treatment in 1881. CONTENTS: Nomenclature; History; Pathology and Morbid Anatomy; Incubation. Influence of Age, Sex and Climate; Symptoms, Diagnosis, Prognosis; Treatmen, Preservative, Suction, Excision; Cupping, Compression and Expression, Cauterization, Results of Cauterization; Treatment continued: Curative, Curara, Oxygen, Turkish Baths, General Treatment; Treatment, Preventive; How to recognize a ' Mad' Dog; Emergencies, and how to Treat them; Curiosities of Literature; The Most Recent Views of the Pathology and Treatment of Hydrophobia. HORATIO RIPLEY BIGELOW, M.D. (1844-1909) served during the Civil War as a 2nd Lieutenant in the United States Marine Corps.