Radioimmunoassay

By: Yalow RS

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1983 COLLECTION OF LANDMARK PAPERS ON RADIOIMMUNOASSAY EDITED BY ROSALYN YALOW, NOBEL LAUREATE WHO DISCOVERED THE TECHNIQUE. 10 1/4 inches tall hardcover, 407 pages, green cloth binding with gilt title to cover and spine, unmarked and near-fine, no dust jacket as issued. PREFACE "In agreeing to edit a Benchmark volume on radioimmunoassay (RIA), I appreciated that there might appear to be a disproportionate number of Papers from my laboratory. I felt less guilty when I reflected on the history of RIA and appreciated that from 1959, when the first paper on the assay of plasma insulin in humans was published, through 1964 only an occasional paper on RIA other than those from our laboratory appeared in prominent U.S. journals of endocrinology and diabetes. During those years, Dr. Solomon A. Berson and I, together with our research fellows, conducted several training courses to introduce RIA to more than 100 investigators. These people subsequently became the cadre that spearheaded the introduction of RIA to laboratories around the world. By the late 1960s, RIA had become a major tool in endocrine laboratories and, soon thereafter, found application bacteriology. Routine RIAs have since found a home in nuclear medicine bacteriology. Routine RIAs have since found a home in nuclear medicine and clinical laboratories and usually are performed with reagents prepared by commercial laboratories. RIAs have become highly automated. However, the papers presented in this volume were prepared in research laboratories in which the motivation for developing the assays was to solve a clinical or physiologic problem that could not be answered at all or as easily without the new methodology. I was pleased with the opportunity to edit this volume since it provided me with an excuse for a nostalgic overview of a field that the late Dr. Berson and I parented. I hope the reader not only will gain scientific insight but also 'ill enjoy as much as I did reviewing the history of RIA." ROSALYN SUSSMAN YALOW (1921 - 2011) was an American medical physicist, and a co-winner of the 1977 Nobel Prize in Physiology or Medicine for development of the radioimmunoassay (RIA) technique. She was the second American woman to be awarded the Nobel Prize Physiology or Medicine after Gerty Cori. Knowing how to type, she won a part-time position as secretary to Dr. Rudolf Schoenheimer, a leading biochemist at Columbia University's College of Physicians and Surgeons. Not believing that any good graduate school would admit and provide financial support to a woman, she took a job as a secretary to Michael Heidelberger, another biochemist at Columbia, who hired her on the condition that she studied stenography. She graduated from Hunter College in January 1941. In mid-February of that aforementioned year she received an offer of a teaching assistantship in physics at the University of Illinois at Urbana-Champaign with the primary reason being that World War II commenced and many men went off to war and the university decided to offer scholarships for women rather than shut down. That summer she took two tuition-free physics courses under government auspices at New York University. At the University of Illinois, she was the only woman among the department's 400 members, and the first since 1917. After graduating, Yalow joined the Bronx Veterans Administration Medical Center to help set up its radioisotope service. There she collaborated with Solomon Berson to develop radioimmunoassay. Originally used to study insulin levels in diabetes mellitus, the technique has since been applied to hundreds of other substances - including hormones, vitamins and enzymes - all too small to detect previously. Despite its huge commercial potential, Yalow and Berson refused to patent the method. In 1968, Yalow was appointed Research Professor in the Department of Medicine at Mount Sinai Hospital, where she later became the Solomon Berson Distinguished Professor at Large. Yalow became a distinguished professor at large at the Albert Einstein College of Medicine at Yeshiva University in 1979.

Title: Radioimmunoassay

Author Name: Yalow RS

Categories: Physiology, Biology, Endocrinology, Immunology, Research, Nobel, Biochemistry, Diabetes,

Edition: First edition

Publisher: Stroudsburg, PA, Hutchinson Ross: 1983

Seller ID: 230

Keywords: biology; endocrinology; Nobel; research; history; diabetes; bacteriology; home; medicine; physiology