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1919 MASSIVE REPORT OF ILLUSTRATED WORLD WARD I CLINICAL RESEARCH STUDY OF SEVERE PROTEIN RESTRICTION BY FRANCIS BENEDICT AND HIS FAMOUS BOSTON NUTRITION LABORATORY.10 inches tall, 2 1/2 inches thick paperbound book with printed title to cover and spine, frontis photograph of Diet and Control Squads and Investigators, International Young Men's Christian Association College, Springfield, Massachusetts, January 11, 1918, institutional library handstamp to title page with deaccession cancel, xi, 701 pp, 124 illustrations. Abrasion lower spine from removal of small library label, archival tape reinforcement of back hinge, covers lightly soiled, front edge chipped, text unmarked and very good. In custom archival mylar cover. FRANCIS GANO BENEDICT (1870 - 1957) was an American chemist, physiologist, and nutritionist who developed a calorimeter and a spirometer used to determine oxygen consumption and measure metabolic rate. Born in Milwaukee, Wisconsin, Benedict attended Harvard University, earning his bachelor's degree in 1893 and his master's degree in 1894. He earned his Ph.D., magna cum laude, at Heidelberg University in 1895. He taught at Wesleyan University and did work for the U.S. Department of Agriculture. He was elected a Fellow of the American Academy of Arts and Sciences in 1909. William Welch and John Shaw Billings were impressed with Benedict's early publications on animal heat and metabolism, and they conviced the Carnegie Foundation trustees to establish a nutrition laboratory under Benedict's direction. The result was the Boston Nutrition Laboratory, where Benedict remained until his retirement (1907-1937). (DSB 1.610/1). REVIEWED IN JAMA, NOV 15, 1919: The Question of Low Protein Diets, Benedict and his collaborators at the Carnegie Nutrition Laboratory in Boston conducted an elaborate investigation on human vitality and efficiency under prolonged restricted diet. result of the diminished food intake with a resulting decrease in body weight, amounting to more than 10 per cent., there was no pronounced decrease in physical endurance or capacity for work. The depression in the total metabolism was the most prominent feature in the research, particuIarly as it was accompanied by a depression in other rate. The changes were accompanied by a large loss of nitrogen from the body, amounting to 175 grams or more per person. Benedict argues that this loss is the most probable cause for the lowering of the plane of metabolism; for the withdrawal of a large amount of nitrogenous material from the fluids bathing the tissue cells is conceived by him to remove a potent stimulus to cellular activity. The report to which we have referred in some detail goes a step farther, however. Experimental evidence has accumulated in sufficient amounts, we are assured, to justify a serious consideration of a material reduction in the intake of protein, which is one of the most expensive factors in human food. Under ordinary conditions of nutrition, fats and carbohydrates may have a marked protein-sparing action; but when the bottom level of nitrogenous exchange is reached, no gains can be made by large increments of nonprotein foods alone in the diet. we may hesitate to accept Benedict's conclusion that for all practical purposes the low protein diet is perfectly justifiable as a war measure and all probability is a logical procedure that cannot be accompanied with any untoward effects, even by long' continued practice. We may, indeed, be forced to accept it as a war measure; but let us hesitate to condemn nitrogen storage in the body until more is known regarding its real physiologic meaning and function.